Molecular Panel Testing of Cancers to Identify Targeted Therapies
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چکیده
There is interest in treating cancers by targeting biological “pathways” that are characterized by specific genetic markers. Genetic panel testing offers the potential to evaluate a large number of genetic markers at a single time to identify treatments that target specific pathways. There are some individual markers that have established benefit in certain types of cancers; these situations are not addressed in this policy. Rather, the focus of this review is on “expanded” panels, which are defined as panels that test a wide variety of genetic markers in cancers without regard for whether specific targeted treatment has demonstrated benefit. This approach may result in a different treatment than usually selected for a patient based on the type of cancer and stage.
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Molecular Panel Testing of Cancers to Identify Targeted Therapies
Currently, there is interest in treating cancers by targeting biological “pathways” that are characterized by specific genetic markers. Genetic panel testing offers the potential to evaluate a large number of genetic markers at a single time to identify treatments that target specific pathways. There are some individual markers that have established benefit in certain types of cancers; these si...
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